eISSN 2325-4415


Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimburse of publication expenses
  2. All reports prepared according to the... read more

Published: 2014-10-16

Bio-Artificial Heart as Ultimate Treatment of End-Stage Heart Failure

Francis Edwin Smit, Pascal Maria Dohmen

(Department of Cardiothoracic Surgery, University of the Free State, Bloemfontein, South Africa)

Med Sci Monit Basic Res 2014; 20:161-163

DOI: 10.12659/MSMBR.892287

Abstract: End-stage heart failure is a major health problem, but implementation of guidelines and optimizing medical therapy for this devastating disease should decrease mortality. If optimal conservative therapy is no longer sufficient, a mechanical support system may be required as final destination therapy or as bridge-to-transplant. Since the first heart transplantation in 1967, this therapy has become the criterion standard for end-stage heart failure, but is limited due to organ shortage. Tissue engineering could help overcome this limitation and provide regeneration, remodeling, and growth potential. This so-called bio-artificial heart would be available, created by a decellularized extracellular matrix and seeded with in vitro proliferated autologous cardiovascular cells. Results of the first experimental studies have been promising, but numerous challenges must be met before this procedure will be available.

Keywords: Heart Failure, Heart Transplantation, Tissue Engineering

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DOI: 10.12659/MSMBR.892450

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