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Published: 2015-05-28

Noninvasive Assessment of Myocardial Mechanics of the Left Ventricle in Rabbits Using Velocity Vector Imaging

Jia Zhou, Da-Rong Pu, Lei-Qi Tian, Hai Tong, Hong-Yu Liu, Yan Tang, Qi-Chang Zhou

(Department of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland))

Med Sci Monit Basic Res 2015; 21:109-115

DOI: 10.12659/MSMBR.894053


BACKGROUND: Our study aimed to investigate the feasibility of velocity vector imaging (VVI) to analyze left ventricular (LV) myocardial mechanics in rabbits at basal state.
MATERIAL AND METHODS: The animals used in this study were 30 New Zealand white rabbits. All rabbits underwent routine echocardiography under VVI-mode at basal state. The 2-dimensional (2-D) echocardiography images acquired included parasternal left long-axis views and short-axis views at the level of LV mitral valve, papillary muscles, and apex. Images were analyzed by VVI software.
RESULTS: At basal state, longitudinal LV velocity decreased from the basal to the apical segment (P<0.05). In the short axis direction, the highest peak myocardial velocity was found between the anterior septum and anterior wall for each segment at the same level; the peak strains and strain rates (SR) were the highest in the anterior and lateral wall compared to other segments (all P<0.05). During systole, LV base rotated in a clockwise direction and LV apex rotated in a counter-clockwise direction, while during diastole, both LV base and apex rotated in the direction opposite to systole. The rotation angle, rotation velocity and unwinding velocity in the apical segment were greater than the basal segment (P<0.05).
CONCLUSIONS: VVI is a reliable tool for evaluating LV myocardial mechanics in rabbits at basal state, and the LV long-axis short-axis and torsional motions reflect the normal regular patterns. Our study lays the foundation for future experimental... read more

Keywords: Anterior Wall Myocardial Infarction, Blood Flow Velocity, Echocardiography, Doppler, Heart Ventricles



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