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Medical Science Monitor Basic Research has been selected for the ESCI - Emerging Sources Citation Index (Thomson Reuters, Web of Science, ISI), launching in November 2015 as a new edition of the Web of read more


Published: 2016-07-23

Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis

Mostafa Samak, Javid Fatullayev, Anton Sabashnikov, Mohamed Zeriouh, Bastian Schmack, Mina Farag, Aron-Frederik Popov, Pascal M. Dohmen, Yeong-Hoon Choi, Thorsten Wahlers, Alexander Weymann

(Department of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom)

Med Sci Monit Basic Res 2016; 22:75-79

DOI: 10.12659/MSMBR.900437


ABSTRACT: Ventricular hypertrophy is an ominous escalation of hemodynamically stressful conditions such as hypertension and valve disease. The pathophysiology of hypertrophy is complex and multifactorial, as it touches on several cellular and molecular systems. Understanding the molecular background of cardiac hypertrophy is essential in order to protect the myocardium from pathological remodeling, or slow down the destined progression to heart failure and cardiomyopathy. In this review we highlight the most important molecular aspects of cardiac hypertrophic growth in light of the currently available published research data.

Keywords: Adaptor Proteins, Signal Transducing, Cardiomyopathy, Hypertrophic, Cell Adhesion Molecules




Published: 2016-07-13

Moving Back to the Future: Use of Organ Care System Lung for Lobectomy Before Lobar Lung Transplantation


Anton Sabashnikov, Mohamed Zeriouh, Prashant N. Mohite, Nikhil P. Patil, Diana García-Sáez, Bastian Schmack, Simona Soresi, Pascal M. Dohmen, Aron-Frederik Popov, Alexander Weymann, André R. Simon, Fabio De Robertis

Med Sci Monit Basic Res 2016; 22:70-74

DOI: 10.12659/MSMBR.900200

Published: 2016-06-30

Frozen Elephant Trunk Technique in a Patient with Multiple Previous Cardiac Procedures: A Case Report


Torsten Christ, Alexander Lembcke, Michael Laule, Pascal Dohmen

Med Sci Monit Basic Res 2016; 22:67-69

DOI: 10.12659/MSMBR.900105