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Effects of YC-1 on Learning and Memory Functions of Aged Rats

Ipek Komsuoglu Celikyurt, Tijen Utkan, Cuneyt Ozer, Nejat Gacar, Feyza Aricioglu

(Department of Pharmacology, Medical Faculty and Experimental Medical Research and Application Center, Kocaeli University, Kocaeli, Turkey)

Med Sci Monit Basic Res 2014; 20:130-137

DOI: 10.12659/MSMBR.891064

Published: 2014-08-21


Background: The aim of this study was to investigate the effects of a potent nitric oxide-guanylate cyclase activator, 3-(5’-hydroxymethyl-2’-furyl)-1-benzylindazole (YC-1), on learning and memory functions in aged rats.
Material and Methods: Rats were divided into 2 groups as 4-month-old and 24-month-old rats. Rats received YC-1 (1 mg/kg/day) for 2 weeks long-term. Morris water maze (MWM) and passive avoidance (PA) tests were used to determine learning and memory functions.
Results: In the MWM test, there is a significant increase in the acquisition latency (1–4 days) of 24-month-old rats. There is a significant reduction in the “time spent in the escape platform’s quadrant” in 24-month-old rats compared to 4-month-old rats in the probe trial of the MWM test. YC-1 treatment reversed the reduction of the “time spent in the escape platform’s quadrant” of 24-month-old rats. In the PA test, there was no significant difference in the 1st-day latency of rats in all groups. On the 2nd day, retention latency significantly decreased in the 24-month-old rats compared to 4-month-olds. YC-1 reversed the diminished retention latency in 24-month-old rats. YC-1 treatment and aging did not affect results of the locomotor activity test or the foot-shock sensitivity test, suggesting our results were not due to a change in motor activity or disability of the animals.
Conclusions: Our findings suggest that activation of the NO-sGC-cGMP pathway plays an important role in spatial and emotional learning and memory functions in aged rats.

Keywords: Avoidance Learning - drug effects, Animals, Aging - physiology, Indazoles - pharmacology, Male, Memory - drug effects, Motor Activity - drug effects, Rats, Wistar, Reaction Time - drug effects



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