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The effects of aging on lymphocyte subgroups in males and females

Ali Inal, Bora Koç, Huseyin Yuce Bircan, Ebru Ogan, Alpaslan Yavuz, Ozgur Kemik

(Department of Immunology, Baskent University, Faculty of Medicine, Istanbul, Turkey)

Med Sci Monit Basic Res 2014; 20:93-96

DOI: 10.12659/MSMBR.891239

Published: 2014-07-12


Background: Age-associated immune senescence is a catch-all phrase that has been used to describe a plethora of changes to the immune system across the lifespan. Aging is associated with a decline in immune function. Our aim in this study was to investigate how lymphocyte subgroups in peripheral blood are affected by aging among males and females.
Material and Methods: Study participants were 70 healthy individuals from 3 different age groups, observed from January 2010 to January 2012. The average levels of CD3+, CD4+, CD8+, CD19+, CD16+/CD56+, CD3+/CD69+, and CD19+/CD69+ were determined for each group and compared in terms of age and sex.
Results: We found significant reduction in the level of CD3+T cells related with age, but no significant changes in CD19+ B cell levels (p<0.005). Aging significantly reduces activated B cell (CD19+/CD69+) levels in males (p<0.005).
Conclusions: Our results show that there may be differences between males and females in terms of immune senescence.

Keywords: Aged, Adult, Aging - immunology, Female, Flow Cytometry, Humans, Lymphocyte Subsets - immunology, Male, Middle Aged



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