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23 July 2016 : Review article  

Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis

Mostafa SamakABCDEF, Javid FatullayevABCDEF, Anton SabashnikovABCDEF, Mohamed ZeriouhABCDEF, Bastian SchmackABCDEF, Mina FaragBCDE, Aron-Frederik PopovBCDE, Pascal M. DohmenBCDEG, Yeong-Hoon ChoiABCDEF, Thorsten WahlersABCDEF, Alexander WeymannABCDEFG

DOI: 10.12659/MSMBR.900437

Med Sci Monit Basic Res 2016; 22:75-79

Abstract

Ventricular hypertrophy is an ominous escalation of hemodynamically stressful conditions such as hypertension and valve disease. The pathophysiology of hypertrophy is complex and multifactorial, as it touches on several cellular and molecular systems. Understanding the molecular background of cardiac hypertrophy is essential in order to protect the myocardium from pathological remodeling, or slow down the destined progression to heart failure and cardiomyopathy. In this review we highlight the most important molecular aspects of cardiac hypertrophic growth in light of the currently available published research data.

Keywords: Adaptor Proteins, Signal Transducing, Cardiomyopathy, Hypertrophic, Cell Adhesion Molecules

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416