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Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis

Mostafa Samak, Javid Fatullayev, Anton Sabashnikov, Mohamed Zeriouh, Bastian Schmack, Mina Farag, Aron-Frederik Popov, Pascal M. Dohmen, Yeong-Hoon Choi, Thorsten Wahlers, Alexander Weymann

(Department of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom)

Med Sci Monit Basic Res 2016; 22:75-79

DOI: 10.12659/MSMBR.900437


ABSTRACT: Ventricular hypertrophy is an ominous escalation of hemodynamically stressful conditions such as hypertension and valve disease. The pathophysiology of hypertrophy is complex and multifactorial, as it touches on several cellular and molecular systems. Understanding the molecular background of cardiac hypertrophy is essential in order to protect the myocardium from pathological remodeling, or slow down the destined progression to heart failure and cardiomyopathy. In this review we highlight the most important molecular aspects of cardiac hypertrophic growth in light of the currently available published research data.

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