Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 1998

LDL-apheresis and its effects on the lipid profile and plasma fibrinogen level in patients with refractory hypercholesterolemia-preliminary report

Ewa Konduracka, Wiesława Piwowarska, Aldona Dembińska-Kieć, Stanisław Bartuś, Łukasz Partyka, Jadwiga Hartwich, Iwona Gołąbek, Izabella Pietrzak, Jerzy Sadowski, Dariusz Dudek

Med Sci Monit 1998; 4(6): CR938-941 :: ID: 451727

Abstract

LDL-apheresis is a method for the extracorporeal removal of LDL-cholesterol and its modified forms in patients with refractory hypercholesterolemia, who are unresponsive towards standard lipid lowering diets as well as drugs. The aim of this study was to analyse the influence of LDL apheresis on blood lipid profile and plasma fibrinogen concentration changes in patients with ischemic heart disease and refractory hypercholesterolemia. The study group comprised six men, aged between 39-54 who underwent coronary angiography and invasive treatment (3-PTCA, 3-CABG). The patients mean total cholesterol level was 7.7 mmol/l and the mean LDL-cholesterol level was 5.7 mmol/l despite a diet and one months treatment with simvastatine (20- 40mg/day). The mean plasma fibrinogen level prior to apheresis was 3.7g/l. Treatment with LDL-apheresis was introduced, two days before the revascularization procedure and continued for a period of one to three months following PTCA or CABG, in order to maintain the LDL-cholesterol level below 2.5 mmol/l. Results: A single LDL apheresis caused reduction of the mean total cholesterol level by 53% and mean LDL-cholesterol level by 65%. Examination of the LDL fraction revealed an increase of resistance towards oxidation performed ex vivo. We also observed a transient decrease in the mean plasma fibrinogen level (by 21%). Conclusions: LDL apheresis is a safe and effective method in the treatment of refractory hypercholesterolemia. Continued therapy with LDL-apheresis decreases coronary artery disease risk factors such as hypercholesterolemia and hyperfibrinogenemia.

Keywords: LDL-apheresis, refractory hypercholesterolemia

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750