01 November 1999
Proliferative activity of metastatic liver tumors based on the evaluation of MAPK sub-unit p42s activity
Tomasz Banasiewicz, Jacek Paszkowski, Tomasz Wierzbicki, Przemysław Pyda, Tadeusz Pawełek, Piotr Gronek, Michał DrewsMed Sci Monit 1999; 5(6): BR1070-1073 :: ID: 503098
Abstract
The aim of this study was to evaluate the activity of the p42 MAPK subunit (mitogen activated protein kinase), one of the most important factors of proliferation and differentiation, in metastatic liver tumors. The material comprised liver biopsies collected from 16 patients during large bowel cancer surgery. We evaluated the activity of MAPK from the central part of each tumor, the border region (between tumor and macroscopically uninvolved liver) and samples located far away from the metastases. This was determined by means of the westernblot technique with IgG antibodies directed against MAPK. 13 cases presented with an increased MAPK level in samples collected from liver tumors. In 9 of 13 cases the highest MAP kinase activity was noted in the peripheral part of the tumor. Our results correlate with the supposed role of the kinase cascade in the formation and growth of metastatic liver tumors. The elevated MAPK level in the peripheral part of the tumor can explain the rapid tumor growth and the high percentage of tumor recurrence following surgery. Thus, in cases of liver metastases the tumor tissue should be resected with a wide margin.
Keywords: MAPK, liver metastases
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952