16 December 2020>: Laboratory Research
Paclitaxel Ameliorates Palmitate-Induced Injury in Mouse Podocytes
Seung Seob Son 1ABCDEF , Jeong Suk Kang 12CDEF , Eun Young Lee 123ACDEFG*DOI: 10.12659/MSMBR.928265
Med Sci Monit Basic Res 2020; 26:e928265
Figure 3 Effect of paclitaxel on palmitate-induced ER stress. Podocytes were treated with 300 μM palmitate with or without paclitaxel for 24 h. (A) Western blots (top) and densitometry (bottom) for ATF-6α and Bip. (B) Real-time PCR for CHOP, spliced XBP1, and Bip was normalized by β-actin mRNA level in the same sample. Error bars represent the mean±SEM. (n=3). BSA – bovine serum albumin; PA – palmitate; PTX – paclitaxel. * P<0.05, ** P<0.01, *** P<0.001 compared with palmitate.