01 February 2004
The effect of hormone replacement therapy on endothelial function in postmenopausal women with hypertensionDanuta Czarnecka, Kalina Kawecka-Jaszcz, Agnieszka Olszanecka, Aldona Dembińska-Kieć, Małgorzata Malczewska-Malec, Anna Zdzienicka, Ibeth Guevara
Med Sci Monit 2004; 10(2): CR55-61 :: ID: 11576
Background:Endothelial dysfunction has been implicated in the pathophysiology of cardiovascular diseases, including arterial hypertension. The present study was undertaken to assess endothelial function in postmenopausal women with arterial hypertension receiving hormone replacement therapy and antihypertensive treatment.Material/Methods: A group of 76 women with natural menopause and essential mild to moderate arterial hypertension entered the study. Forty women received a transdermal, combined hormone replacement therapy (HRT) of 17ß-estradiol and norethisterone acetate, whereas 36 served as controls. At baseline and at 3 and 12 months, all patients underwent 24-hr blood pressure monitoring and an exercise test, before which, at peak exercise, and after a 15-min recovery period venous blood was drawn to measure the level of nitrite/nitrate (NOx) according to the Griess method.Results: At 3 and 12 months after beginning HRT, the level of NOx at rest was slightly increased, with marked individual differences in response to HRT. In women not receiving HRT, NOx did not change. In the HRT group, 52.5% at 3 months and 47.5% at 12 months had significantly increased levels compared with the baseline values (17.8±6.7 vs. 32.8±4.5 vs. 28.7±1.1 Kmol/l; p=0.002). The increased NOx level in responders was associated with decreased LDL cholesterol (3.62±1.2 vs. 3.53±1.3 vs. 2.6±0.6 mmol/l; p=0.01). At 12 months, blood pressure values did not differ from those at baseline in either group.Conclusions: The significant increase of NOx in half of the women receiving HRT suggests that only responders experience the cardioprotective effects of HRT.
Keywords: Administration, Cutaneous, Antihypertensive Agents - therapeutic use, Blood Pressure - drug effects, Blood Pressure - physiology, Blood Pressure Monitoring, Ambulatory, Cholesterol, LDL - blood, Drug Combinations, Endothelium, Vascular - drug effects, Endothelium, Vascular - physiology, Estradiol - administration & dosage, Estradiol - blood, Estradiol - pharmacology, Follicle Stimulating Hormone - blood, Follow-Up Studies, Hormone Replacement Therapy, Hypertension - drug therapy, Hypertension - physiopathology, Nitric Oxide - blood, Nitrites - blood, Norethindrone - administration & dosage, Norethindrone - pharmacology, Postmenopause - drug effects, Postmenopause - physiology, Time Factors, Administration, Cutaneous, Antihypertensive Agents - therapeutic use, Blood Pressure - physiology, Blood Pressure Monitoring, Ambulatory, Cholesterol, LDL - blood, Drug Combinations, Endothelium, Vascular - physiology, Estradiol - pharmacology, Follicle Stimulating Hormone - blood, Follow-Up Studies, Hormone Replacement Therapy, Hypertension - physiopathology, Nitric Oxide - blood, Nitrites - blood, Norethindrone - pharmacology, Postmenopause - physiology, Time Factors
Most Viewed Current Articles
13 Apr 2020 : Original articleOutcome of 24 Weeks of Combined Schroth and Pilates Exercises on Cobb Angle, Angle of Trunk Rotation, Chest...
Med Sci Monit Basic Res 2020; 26:e920449
11 May 2020 : Original articleAnalysis of Psychological and Sleep Status and Exercise Rehabilitation of Front-Line Clinical Staff in the ...
Med Sci Monit Basic Res 2020; 26:e924085
05 Jan 2021 : Review articleA Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...
Med Sci Monit Basic Res 2021; 27:e929207
10 Aug 2020 : Clinical ResearchEffects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Rando...
Med Sci Monit Basic Res 2020; 26:e925264