Logo Medical Science Monitor Basic Research

Call: 1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research

01 August 2005

Physiology and pathophysiology of glucagon-like peptide-1 (GLP-1): The role of GLP-1 in the pathogenesis of diabetes mellitus, obesity, and stress.

Ewa Bojanowska

Med Sci Monit 2005; 11(8): RA271-278 :: ID: 202792

Abstract

Glucagon-like peptide-1 (GLP-1) is produced both in the human and rat intestineand brain. The release of GLP-1 into the blood is mediated by factors of neural and hormonal origin andis stimulated by the presence of nutrients in the digestive tract, while the enzyme dipeptidyl peptidaseIV and the kidneys are responsible for, respectively, the rapid degradation and excretion of the hormone.Peripherally secreted GLP-1 enhances insulin synthesis and release and maintains the normal anatomicalstatus of pancreatic islets. Diminished GLP-1 response to ingested food, associated with attenuated insulinrelease and glucose intolerance, was found in non-insulin-dependent diabetes mellitus. GLP-1 replacementin diabetic subjects normalized these parameters, thus indicating a role for this peptide in the pathogenesisof type 2 diabetes. GLP-1 might also be involved in the pathophysiology of obesity and stress to someextent. Both peripheral and central GLP-1 are probably involved in the control of feeding centers asan anorexic agent. GLP-1 affects the activity of the hypothalamo-pituitary-adrenal axis both under basaland stress conditions, including taste aversion learning. Hence, GLP-1-dependent pathophysiological mechanismsmay participate in the pathogenesis of the most common metabolic and behavioral disorders.

Keywords: Obesity - metabolism, Peptide Fragments - secretion, Protein Precursors - secretion, Diabetes Mellitus - metabolism, Glucagon - secretion, Glucagon-Like Peptide 1, Obesity - metabolism, Pancreas - metabolism, Peptide Fragments - secretion, Protein Precursors - secretion, Stress, Physiological - metabolism

0 Comments

Most Viewed Current Articles

13 Apr 2020 : Original article  

Outcome of 24 Weeks of Combined Schroth and Pilates Exercises on Cobb Angle, Angle of Trunk Rotation, Chest...

DOI :10.12659/MSMBR.920449

Med Sci Monit Basic Res 2020; 26:e920449

11 May 2020 : Original article  

Analysis of Psychological and Sleep Status and Exercise Rehabilitation of Front-Line Clinical Staff in the ...

DOI :10.12659/MSMBR.924085

Med Sci Monit Basic Res 2020; 26:e924085

05 Jan 2021 : Review article  

A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...

DOI :10.12659/MSMBR.929207

Med Sci Monit Basic Res 2021; 27:e929207

10 Aug 2020 : Clinical Research  

Effects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Rando...

DOI :10.12659/MSMBR.925264

Med Sci Monit Basic Res 2020; 26:e925264

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416