Logo Medical Science Monitor Basic Research

Call: 1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research

22 February 2002

Vitamin C concentration in gastric juice in patients with precancerous lesions of the stomach and gastric cancer.

Mirosław Jarosz, Maria Wartanowicz, Elzbieta Dabrowska-Ufniarz, Jan Dzieniszewski

Med Sci Monit 2002; 8(2): CR96-103 :: ID: 420933

Abstract

BACKGROUND: The aim of the study was to elucidate what are the concentrationsof vitamin C in gastric juice in patients with gastric cancer in comparison to patients with metaplasia.MATERIAL/METHODS: In patients aged 20 to 75 years with H. pylori infection and chronic gastritis, metaplasiaand gastric cancer the concentration of vitamin C was determined by spectrofotometry of gastric juiceduring gastroscopy. On the basis of the results of histological examination the following four groupswere isolated. Group I (control)--12 patients with normal gastric mucosa, group II--15 patients withchronic gastritis, group III--17 patients with metaplasia and group IV--16 patients with gastric cancerH. pylori infection was confirmed by urease test and histological examination (Giemsa stainning) in allpatients. RESULTS: In controls the mean concentration of vitamin C in gastric juice was 18.2 mg/ml (5.7-31.2mg/ml), in group II--6.3 mg/ml (2.9-13.1 mg/ml) in group III--3.9 mg/ml (2.6-10.1 mg/ml) and group IV--3.2mg/ml (1.7-9.2 mg/ml). Statistically significant differences of vitamin C concentration were found among group I and group II, III and IV (p<0.001) and among groups II and III and IV (p<0.01).
Conclusions: There are not differences of vitamin C concentration in gastric juice between patients with metaplasia and patients with gastric cancer. This points out that low levels of this vitamin in gastric juice might play the role in the earlier stages of carcinogenesis.

Keywords: Ascorbic Acid, Gastric Juice, Gastroscopy, Helicobacter Infections, Helicobacter pylori, Hydrogen-Ion Concentration, Precancerous Conditions, Stomach Neoplasms

Comments

Most Viewed Current Articles

13 Apr 2020 : Original article  

Outcome of 24 Weeks of Combined Schroth and Pilates Exercises on Cobb Angle, Angle of Trunk Rotation, Chest...

DOI :10.12659/MSMBR.920449

Med Sci Monit Basic Res 2020; 26:e920449

11 May 2020 : Original article  

Analysis of Psychological and Sleep Status and Exercise Rehabilitation of Front-Line Clinical Staff in the ...

DOI :10.12659/MSMBR.924085

Med Sci Monit Basic Res 2020; 26:e924085

05 Jan 2021 : Review article  

A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...

DOI :10.12659/MSMBR.929207

Med Sci Monit Basic Res 2021; 27:e929207

10 Aug 2020 : Clinical Research  

Effects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Rando...

DOI :10.12659/MSMBR.925264

Med Sci Monit Basic Res 2020; 26:e925264

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416