Logo Medical Science Monitor Basic Research

Call: 1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research

18 May 2007

Magnetic Resonance evaluation of disease activity in Graves' ophthalmopathy: T2-time and signal intensity of extraocular muscles.

Agata Majos, Michał Pająk, Marcin Elgalal, Piotr Grzelak, Ludomir Stefańczyk

Med Sci Monit 2007; 13(1): 44-48 :: ID: 482354

Abstract

Background: It is accepted that T2-weighted imaging can demonstrate the extent of an inflammatory process in Graves' ophthalmopathy (GO). This aim of this study was a comparative evaluation of the most commonly used indicators of extraocular muscle pathophysiology, i.e. signal intensity (SI) and T2-time (T2-t) in correlation with muscle volume (MV), and to determine the need to make the above indicators objective with regards to clinical practice. Material/Methods: MRI examinations in a 1.5 T scanner of 40 orbits formed the study group. Quantitative assessment of the muscles was carried out using a numerical segmentation imaging technique (NSI). SI and T2-t were measured for each muscle. A standardization algorithm was applied based on T2-t and IS from the ipsilateral white matter of the frontal lobes. Results: The correlation between T2-t and MV for the medial rectus and inferior rectus muscles (IRM) was at a comparatively high level (R: 0.49 and 0.47), with a value as high as R=0.58 for the superior rectus muscle. Correlation between SI and volume for these muscles was found to be at R-levels of 0.37, 0.48, and 0.46. Correction of the T2-t and SI values with use of a standardization algorithm in most cases did not change the above correlations, except for IRM. Conclusions: The parameter with the higher correlation to the symptoms of GO is T2 The value of SI as an indicator of disease intensity in GO that can be used without the use of multiple echo sequences was confirmed. It is necessary to make the above parameters objective relative to white matter when calculating IS for the inferior rectus muscle.

Keywords: Disease Progression, Graves Ophthalmopathy - physiopathology, Magnetic Resonance Imaging, Oculomotor Muscles - physiopathology, Statistics as Topic

Comments

Most Viewed Current Articles

13 Apr 2020 : Original article  

Outcome of 24 Weeks of Combined Schroth and Pilates Exercises on Cobb Angle, Angle of Trunk Rotation, Chest...

DOI :10.12659/MSMBR.920449

Med Sci Monit Basic Res 2020; 26:e920449

11 May 2020 : Original article  

Analysis of Psychological and Sleep Status and Exercise Rehabilitation of Front-Line Clinical Staff in the ...

DOI :10.12659/MSMBR.924085

Med Sci Monit Basic Res 2020; 26:e924085

05 Jan 2021 : Review article  

A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...

DOI :10.12659/MSMBR.929207

Med Sci Monit Basic Res 2021; 27:e929207

10 Aug 2020 : Clinical Research  

Effects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Rando...

DOI :10.12659/MSMBR.925264

Med Sci Monit Basic Res 2020; 26:e925264

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416