Logo Medical Science Monitor Basic Research

Call: 1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research

01 March 1996

Blood levels of plasminogen and alpha-2-antiplasmin in patients with prostatic carcinoma

Izabela Iwan-Ziętek, Maria Kotschy, Ewa Wiśniewska, Zbigniew Wolski

Med Sci Monit 1996; 2(2): CR183-186 :: ID: 499563

Abstract

Activation of fibrinolysis resulting in bleeding was observed in patients with prostatic carcinoma. The aim of this study was to estimate the level of plasminogen, a precursor of plasmin and α2,-antiplasmin, its main inhibitor. Blood samples were obtained from 20 patients with prostatic carcinoma and benign prostatic hyperplasia. In three patients with carcinoma massive haematuria was observed. α2,-antiplasmin activity in patients with carcinoma was found to be lower than that in patients with benign prostatic hyperplasia. Plasminogen level in both groups was normal. Additionally, routine fibrinolysis parameters were evaluated which proved to be normal except for the bleeding patients. Apart from the decreased α2,-antiplasmin activity and plasminogen level, the latter group showed a reduced euglobulin lysis time (ELT), increased level of fibrin degradation products (FDP), prolonged kaolin-kephalin time (aPTT) and low platelet count. The altered values of the parameters are, presumably, the evidence of the activation of fibrinolysis. The authors believe that patients with prostatic carcinoma are at higher risk of developing bleeding that those with benign prostatic hyperplasia.

Keywords: prostatics carcinoma, Fibrinolysis, alpha2-antiplasmin, bleeding

0 Comments

Most Viewed Current Articles

13 Apr 2020 : Original article  

Outcome of 24 Weeks of Combined Schroth and Pilates Exercises on Cobb Angle, Angle of Trunk Rotation, Chest...

DOI :10.12659/MSMBR.920449

Med Sci Monit Basic Res 2020; 26:e920449

11 May 2020 : Original article  

Analysis of Psychological and Sleep Status and Exercise Rehabilitation of Front-Line Clinical Staff in the ...

DOI :10.12659/MSMBR.924085

Med Sci Monit Basic Res 2020; 26:e924085

05 Jan 2021 : Review article  

A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...

DOI :10.12659/MSMBR.929207

Med Sci Monit Basic Res 2021; 27:e929207

10 Aug 2020 : Clinical Research  

Effects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Rando...

DOI :10.12659/MSMBR.925264

Med Sci Monit Basic Res 2020; 26:e925264

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416