01 November 1996
Application of studies of nucleolar organizer regions (NORs) to clinical and morphological diagnosis, particularly in lung cancer
Daniel Sabat, Jerzy K. Nożyński, Zbigniew Szczurek, Andrzej GabrielMed Sci Monit 1996; 2(6): CR720-726 :: ID: 500125
Abstract
Expression marking of nucleolar organising regions (NORs) is a modern quantitative diagnostic method applied more widely in evaluation of proliferating activity of tumour cells. A particular interest has been observed since 1986, i.e., since a report by Ploton on a simple colloid method of one-stage protein silverstaining. This allowed a quantitative evaluation of the regions on light microscopy. The present study describes application of marking of argyrophil granules (Ag-NORs) in different tumours and precancerous stages mainly to differentiate borderline lesions. Particular emphasis is paid to the use of the granulation marking in diagnosing small and non-small cell lung carcinoma. The study presents a number of controversies on dependence of Ag-NOR expression on the histological type, clinical stage and tumour mass doubling time as well as views on little usefulness of Ag-NORs in differentiating particular types of carcinomas. Alternating study methods of granules in the cell nucleus from tissue and cytological material, the application of computer analysis and Ag-NOR method assisted by immunohistochemical techniques are also discussed.
Keywords: nucleolar organiser regions, lung cancer
Most Viewed Current Articles
13 Apr 2020 : Original article
Outcome of 24 Weeks of Combined Schroth and Pilates Exercises on Cobb Angle, Angle of Trunk Rotation, Chest...DOI :10.12659/MSMBR.920449
Med Sci Monit Basic Res 2020; 26:e920449
11 May 2020 : Original article
Analysis of Psychological and Sleep Status and Exercise Rehabilitation of Front-Line Clinical Staff in the ...DOI :10.12659/MSMBR.924085
Med Sci Monit Basic Res 2020; 26:e924085
05 Jan 2021 : Review article
A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...DOI :10.12659/MSMBR.929207
Med Sci Monit Basic Res 2021; 27:e929207
10 Aug 2020 : Clinical Research
Effects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Rando...DOI :10.12659/MSMBR.925264
Med Sci Monit Basic Res 2020; 26:e925264