01 November 1999
Proliferative activity of metastatic liver tumors based on the evaluation of MAPK sub-unit p42s activityTomasz Banasiewicz, Jacek Paszkowski, Tomasz Wierzbicki, Przemysław Pyda, Tadeusz Pawełek, Piotr Gronek, Michał Drews
Med Sci Monit 1999; 5(6): BR1070-1073 :: ID: 503098
The aim of this study was to evaluate the activity of the p42 MAPK subunit (mitogen activated protein kinase), one of the most important factors of proliferation and differentiation, in metastatic liver tumors. The material comprised liver biopsies collected from 16 patients during large bowel cancer surgery. We evaluated the activity of MAPK from the central part of each tumor, the border region (between tumor and macroscopically uninvolved liver) and samples located far away from the metastases. This was determined by means of the westernblot technique with IgG antibodies directed against MAPK. 13 cases presented with an increased MAPK level in samples collected from liver tumors. In 9 of 13 cases the highest MAP kinase activity was noted in the peripheral part of the tumor. Our results correlate with the supposed role of the kinase cascade in the formation and growth of metastatic liver tumors. The elevated MAPK level in the peripheral part of the tumor can explain the rapid tumor growth and the high percentage of tumor recurrence following surgery. Thus, in cases of liver metastases the tumor tissue should be resected with a wide margin.
Keywords: MAPK, liver metastases
Most Viewed Current Articles
31 Dec 1969 : Original articleOutcome of 24 Weeks of Combined Schroth and Pilates Exercises on Cobb Angle, Angle of Trunk Rotation, Chest...
Med Sci Monit Basic Res 2020; 26:e920449
31 Dec 1969 : Original articleAnalysis of Psychological and Sleep Status and Exercise Rehabilitation of Front-Line Clinical Staff in the ...
Med Sci Monit Basic Res 2020; 26:e924085
31 Dec 1969 : Review articleA Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...
Med Sci Monit Basic Res 2021; 27:e929207
31 Dec 1969 : Clinical ResearchEffects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Rando...
Med Sci Monit Basic Res 2020; 26:e925264