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01 June 2011

The relationship between levels of von Willebrand factor and mean platelet volume in subjects with isolated impaired fasting glucose

Feyzi BostanABEF, Erkan CobanACDEF

DOI: 10.12659/MSM.881786

Med Sci Monit 2011; 17(6): PR1-4

Abstract

ABSTRACT: Background: To understand the heterogeneity of platelets, we investigated the correlation between von Willebrand factor (vWf) and mean platelet volume (MPV) in subjects with isolated impaired fasting glucose (IFG). Material/Methods: We selected 48 subjects with isolated IFG and 48 normoglycemic control subjects matched for age, sex, and body mass index. We measured levels of vWf and MPV in all subjects. Results: The levels of vWf and MPV were significantly higher in the isolated IFG group than the control group (p<0.05) Also, vWf level was positively correlated with MPV level in subjects in the isolated IFG group (r=0.452, p=0.001). Conclusions: Our results suggest that vWf seems to be profoundly related to platelet volume in subjects with isolated IFG.

Keywords: Fasting - blood, Cell Size, Blood Platelets - cytology, Blood Glucose - metabolism, von Willebrand Factor - metabolism

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416