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Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis

Fariba Almassinokiani, Abolfazl Mehdizadeh, Elahe Sariri, Mansour Rezaei, Alireza Almasi, Hossein Akbari, Abdolreza Pazooki, Masoud Solaymani-Dodaran, Sara Asadollah, Jila Amirkhani, Shahla Chaichian, Mansoureh Vahdat, Ashrafsadat Moosavi, Monir Ashouri, Zeinab Tamannaei

Med Sci Monit 2013; 19:534-539

DOI: 10.12659/MSM.883967

Available online:

Published: 2013-07-05

Background: To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.
Material and Methods: Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses.
Results: Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05).
Conclusions: Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis.

Keywords: Marital Status, Laparoscopy - adverse effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use, Endometriosis - surgery, Adult, Pain, Postoperative - prevention & control, Recurrence, Simvastatin - therapeutic use