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21 April 2014 : Review article  

The association of Restless Legs Syndrome with hypertension and cardiovascular disease

Vasiliki KatsiABCDEFG, Themistoklis KatsimichasDE, Manolis S. KallistratosDE, Dora TsekouraCDE, Thomas MakrisD, Athanasios J. ManolisD, Dimitris TousoulisD, Christodoulos StefanadisD, Ioannis KallikazarosD

DOI: 10.12659/MSM.890252

Med Sci Monit 2014; 20:654-659

Abstract

ABSTRACT: Restless Legs Syndrome (RLS), is a sensory-motor neurological disorder that appears to be surprisingly common in the community. Periodic limb movements in sleep are typically encountered in more than 80% of RLS patients and comprise involuntary muscular jerks in the lower limbs, such as flexion of the knees or ankles.  Iron deficiency and dopaminergic neuronal dysfunction in the central nervous system are currently thought to be the likely pathophysiological culprits. There is evidence linking RLS to hypertension and cardiovascular disease. This short review will first present a synopsis of epidemiological, clinical and pathophysiological data concerning the syndrome, and then information on the possible links between RLS and cardiovascular disorders

Keywords: Hypertension - complications, Cardiovascular Diseases - complications, Restless Legs Syndrome - physiopathology

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416