Polymorphism of ABCB1/MDR1 C3435T in Children and Adolescents with Partial Epilepsy is due to Different Criteria for Drug Resistance – Preliminary Results
Ewa Emich-Widera, Wirginia Likus, Beata Kazek, Aleksander L. Sieroń, Ksymena Urbanek
Department of Neuropediatrics, School of Medicine, Medical University of Silesia, Katowice, Poland
Med Sci Monit 2014; 20:1654-1661
The diagnosis of “drug resistance” in epilepsy can be defined and interpreted in various ways. This may be due to discrepant definitions of drug resistance to pharmacotherapy.
The aim of our study was to investigate the relationship between C3435T polymorphism of the MDR1 gene and drug resistance in epilepsy with the consideration of 4 different criteria for qualification to groups sensitive and resistant to applied pharmacotherapy.
Material and Methods: Evaluation of C3435T polymorphism of MDR1/ABCB1 gene was conducted on a group of 82 white children and young adolescents up to 18 years old. While qualifying the patients to the group of sensitive or drug resistant, the following 4 definitions of drug resistance were applied: the ILAE’s, Appleton’s, Siddiqui’s, and Berg’s.
Results: A detailed analysis of genotypes of the MDR1 gene did not show any significant discrepancies between the groups of patients resistant and sensitive to antiepileptic drugs (AEDs) in 4 consecutive comparisons taking into consideration various criteria of sensitivity and resistance to pharmacotherapy.
Conclusions: The obtained results clearly confirm the lack of a connection between the occurrence of drug-resistant epilepsy and C435T polymorphism of the MDR1 gene irrespective of the definition of drug resistance applied to the patient.
Keywords: Anticonvulsants - therapeutic use, Alleles, Adolescent, Child, Drug Resistance - genetics, Epilepsies, Partial - genetics, Gene Frequency, P-Glycoproteins - genetics, Polymorphism, Single Nucleotide - genetics