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A Cross-Sectional Study of the Relationship Between Serum Liver Enzymes Level and the Incidence of Impaired Fasting Glucose in Males and Females

Guangming Qin, Lihong Lu, Yufei Xiao, Yimiao Zhu, Wensheng Pan, Xiang Xu, Shengrong Shen, Undurti N. Das

Department of Laboratory, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (mainland)

Med Sci Monit 2014; 20:1319-1325

DOI: 10.12659/MSM.890698

Available online:

Published: 2014-07-28

Background: The aim of this study was to investigate the possible correlation between levels of serum liver enzymes and impaired fasting glucose (IFG) in Chinese adults and to provide a new perspective for the prevention of pre-diabetes.
Material and Methods: Serum liver enzymes of the samples including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and g-glutamyl transferase (GGT), as well as plasma glucose, blood lipids, and insulin, were measured. The cumulative incidences of IFG between different quartiles of liver enzymes were compared by the chi-square test. A logistic regression model (binary regression) was used to calculate the odds ratio (OR) of IFG with 95% confidence interval (95% CI).
Results: The total incidence of IFG was 20.3% and the cumulative incidence of IFG was higher in men compared to women. In both sexes, IFG is more prevalent in higher quartiles of liver enzymes. After adjusting for age, BMI, blood pressure, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC), the cumulative incidences of IFG were significantly higher in the highest quartiles of liver enzymes than in the lowest quartiles. A significantly higher cumulative incidence of IFG was found in the highest GGT quartile than in the lowest quartile for woman.
Conclusions: The results of this study suggest that serum liver enzymes are related to the risk of IFG in Chinese adults. We infer that preserving the hepatic function may be an efficient way to prevent the development of IFG, especially in males.

Keywords: Alanine Transaminase - blood, Adult, Aspartate Aminotransferases - blood, Blood Glucose, China - epidemiology, Cross-Sectional Studies, Enzymes - blood, Incidence, Insulin - blood, Lipids - blood, Liver - enzymology, Logistic Models, Odds Ratio, Prediabetic State - prevention & control