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Coenzyme Q10 Supplementation Decreases Statin-Related Mild-to-Moderate Muscle Symptoms: A Randomized Clinical Study

Ajda Skarlovnik, Miodrag Janić, Mojca Lunder, Martina Turk, Mišo Šabovič

Department of Vascular Diseases, University of Ljubljana Medical Centre, Ljubljana, Slovenia

Med Sci Monit 2014; 20:2183-2188

DOI: 10.12659/MSM.890777

Available online:

Published: 2014-11-06


Background: Statin use is frequently associated with muscle-related symptoms. Coenzyme Q10 supplementation has yielded conflicting results in decreasing statin myopathy. Herein, we tested whether coenzyme Q10 supplementation could decrease statin-associated muscular pain in a specific group of patients with mild-to-moderate muscle symptoms.
Material and Methods: Fifty patients treated with statins and reporting muscle pain were recruited. The Q10 group (n=25) received coenzyme Q10 supplementation over a period of 30 days (50 mg twice daily), and the control group (n=25) received placebo. The Brief Pain Inventory (BPI) questionnaire was used and blood testing was performed at inclusion in the study and after 30 days of supplementation.
Results: The intensity of muscle pain, measured as the Pain Severity Score (PSS), in the Q10 group was reduced from 3.9±0.4 to 2.9±0.4 (P<0.001). The Pain Interference Score (PIS) after Q10 supplementation was reduced from 4.0±0.4 to 2.6±0.4 (P<0.001). In the placebo group, PSS and PIS did not change. Coenzyme Q10 supplementation decreased statin-related muscle symptoms in 75% of patients. The relative values of PSS and PIS significantly decreased (–33.1% and –40.3%, respectively) in the Q10 group compared to placebo group (both P<0.05). From baseline, no differences in liver and muscle enzymes or cholesterol values were found.
Conclusions: The present results show that coenzyme Q10 supplementation (50 mg twice daily) effectively reduced statin-related mild-to-moderate muscular symptoms, causing lower interference of statin-related muscular symptoms with daily activities.

Keywords: Adult, Activities of Daily Living, Dietary Supplements, Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects, Muscles - pathology, Myalgia - drug therapy, Pain Measurement, Placebos, Ubiquinone - therapeutic use



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