Zhigang Liu, Peijie Li, Jinrong Wang, Qing Fan, Ping Yan, Xiaojing Zhang, Bo Han
Department of Pediatrics, Jinan Maternal and Child Health Hospital, Shandong University, Jinan, Shandong, China (mainland)
Med Sci Monit 2014; 20:2617-2623
Background: IL13–1112C/T and +2044A/G polymorphisms have been reported to be correlated with pediatric asthma susceptibility, but study results were still debatable. Thus, a meta-analysis was conducted.
Material/Methods: PubMed and EMBASE databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model or fixed-effects model.
Results: Fourteen case-control studies with 4710 asthma cases and 6086 controls were included in this meta-analysis. IL13–1112C/T and +2044A/G polymorphisms were significantly associated with an increased risk of pediatric asthma (OR=1.14, 95% CI 1.01–1.28, P=0.04, I2=0%; OR=1.20, 95% CI 1.09–1.32, P<0.01, I2=0%), respectively. In the subgroup analysis by ethnicity, IL13–1112C/T polymorphism was significantly associated with pediatric asthma risk in whites (OR=1.29, 95% CI 1.02–1.63, P=0.03, I2=16%). IL13 +2044A/G polymorphism was significantly associated with pediatric asthma risk in Asians (OR=1.21, 95% CI 1.10–1.34, P<0.01, I2=24%).
Conclusions: The results of this meta-analysis suggest that IL13–1112C/T and +2044A/G polymorphisms contribute to the development of pediatric asthma.
Keywords: Child, Case-Control Studies, Asthma - genetics, Genetic Association Studies, Genetic Predisposition to Disease, Interleukin-13 - genetics, Polymorphism, Single Nucleotide - genetics, Risk Factors