Ali Inal, Bora Koç, Huseyin Yuce Bircan, Ebru Ogan, Alpaslan Yavuz, Ozgur Kemik
Department of Immunology, Baskent University, Faculty of Medicine, Istanbul, Turkey
Med Sci Monit Basic Res 2014; 20:93-96
Age-associated immune senescence is a catch-all phrase that has been used to describe a plethora of changes to the immune system across the lifespan. Aging is associated with a decline in immune function. Our aim in this study was to investigate how lymphocyte subgroups in peripheral blood are affected by aging among males and females.
Material and Methods: Study participants were 70 healthy individuals from 3 different age groups, observed from January 2010 to January 2012. The average levels of CD3+, CD4+, CD8+, CD19+, CD16+/CD56+, CD3+/CD69+, and CD19+/CD69+ were determined for each group and compared in terms of age and sex.
Results: We found significant reduction in the level of CD3+T cells related with age, but no significant changes in CD19+ B cell levels (p<0.005). Aging significantly reduces activated B cell (CD19+/CD69+) levels in males (p<0.005).
Conclusions: Our results show that there may be differences between males and females in terms of immune senescence.
Keywords: Adult, Aging - immunology, Lymphocyte Subsets - immunology