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Relationships of Urinary VEGF/CR and IL-6/CR with Glomerular Pathological Injury in Asymptomatic Hematuria Patients

Lu Ma, Yinghe Gao, Guanglei Chen, Junhua Gong, Dan Yang, Yongxin Xie, Mingcui Wang, Hong Chen, Minghui Song

Integrated Chinese and Western Medicine Treatment of Renal Disease Centre, Beidaihe Sanatorium of Beijing Military Area Command, Chinese PLA, Qinhuangdao, China (mainland)

Med Sci Monit 2015; 21:356-362

DOI: 10.12659/MSM.892085

Available online:

Published: 2015-01-30

Background: Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) have important functions in injury and repair processes of glomerular intrinsic cells. A study was conducted to analyze the urinary VEGF/creatinine (CR) and IL-6/CR levels in simple hematuria patients after excluding the interference of creatinine. We aimed to investigate the function and relationships of the above indices in the glomerular pathological injury process, and to elaborate the values of urinary VEGF and IL-6 changes in the diagnosis of asymptomatic hematuria or hematuria with proteinuria.
Material and Methods: A total of 121 renal hematuria patients diagnosed by clinical and laboratory tests were included as research subjects. The midstream fresh morning urine was collected on the day renal biopsy was performed.
Results: The IL-6/CR value of the group III was significantly greater than in group I (Z=–2.478, P<0.05), with a statistically significant difference between these 2 groups. The VEGF/CR value of group III was significantly greater than in group II (P<0.01). Compared with group I, the VEGF/CR of group III was significantly greater (Z=–4.65, P<0.01), with a statistically significant difference.
Conclusions: The VEGF/CR and IL-6/CR values in simple hematuria patients were positively correlated with glomerular pathological injury scores. VEGF/CR and IL-6/CR might be used as biological diagnostic indicators in determining the extent of simple hematuria glomerular injury.

Keywords: Case-Control Studies, Biopsy, Creatinine - urine, Cytokine Receptor gp130 - metabolism, Hematuria - urine, Interleukin-6 - urine, Kidney Diseases - urine, Kidney Glomerulus - pathology, Proteinuria - urine, Vascular Endothelial Growth Factor A - urine