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Prognostic Role of MicroRNA-21 in Gastric Cancer: a Meta-Analysis

Zhenqiang Wang, Qiang Cai, Zhaoyan Jiang, Bingya Liu, Zhenggang Zhu, Chen Li

Department of Surgery, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (mainland)

Med Sci Monit 2014; 20:1668-1674

DOI: 10.12659/MSM.892096

Available online:

Published: 2014-09-18

Background: Mounting evidence shows that microRNAs may be useful as prognostic biomarkers of gastric cancer. The aim of this meta-analysis was to summarize the predictive role of miR-21 for survival in patients with gastric cancer and to verify the association between expression of miR-21 and clinical characteristics.
Material and Methods: All the eligible studies were searched by PubMed and EMBASE and clinical characteristics and survival results were extracted. Then a meta-analysis was carried out to clarify the prognostic role of the miR-21 expression in different subgroups.
Results: We included 8 studies dealing with gastric cancer in this meta-analysis. For overall survival, the pooled hazard ratio of higher miR-21 expression in tumor tissue was 2.00 (95% CI: 1.39–2.88, P<0.01), which could significantly predict poorer survival in gastric cancer patients. Importantly, subgroup analysis suggested that higher expression of miR-21 correlated with tumor differentiation 0.42 (95% CI: 0.25–0.70 p<0.01), lymph node metastasis 6.39(95% CI: 3.11–13.14, P<0.01), and TNM stage 0.38 (95% CI: 0.21–0.67, P<0.01).
Conclusions: This meta-analysis indicates that miR-21 detection has a prognostic value in patients with gastric cancer. In addition, overexpression of miR-21 is associated with worse tumor differentiation, lymph node metastasis, and TNM stage.

Keywords: Gene Expression Regulation, Neoplastic, Lymph Nodes - pathology, MicroRNAs - metabolism, Prognosis, Publication Bias, Stomach Neoplasms - genetics, Survival Analysis