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Gene Polymorphisms of Adducin GLY460TRP, ACE I/D, AND AGT M235T in Pediatric Hypertension Patients

İbrahim Kaplan, Enver Sancaktar, Aydın Ece, Velat Şen, Nilgün Tekkeşin, Mustafa Kemal Basarali, Selvi Kelekci, Osman Evliyaoglu

Department of Medical Biochemistry, Dicle University, Diyarbakir, Turkey

Med Sci Monit 2014; 20:1745-1750

DOI: 10.12659/MSM.892140

Available online:

Published: 2014-09-28

Background: Hypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric population with secondary hypertension.
Material and Methods: Included in the study were 58 hypertensive and 58 normotensive pediatric patients. ACE I/D and AGT M235T polymorphisms are determined by conventional PCR; ADD Gly460Trp polymorphism was investigated using PCR amplification of genomic DNA.
Results: There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.
Conclusions: We suggest that RAS gene polymorphisms (ACE-I/D, AGT M235T) are significantly associated with susceptibility to diseases that lead to secondary hypertension.

Keywords: Angiotensinogen - genetics, Alleles, Calmodulin-Binding Proteins - genetics, Case-Control Studies, Child, Gene Frequency, Genetic Predisposition to Disease, Hypertension - genetics, Peptidyl-Dipeptidase A - genetics, Polymorphism, Single Nucleotide - genetics, Renal Insufficiency, Chronic - genetics