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Impact of Patent Ductus Arterıosus and Subsequent Therapy with Ibuprofen on The Release of S-100B and Oxıdatıve Stress Index in Preterm Infants

Nihat Demir, İbrahim Ece, Erdal Peker, Sultan Kaba, Lokman Ustyol, Ragıp Balahoroğlu, Oğuz Tuncer

Department of Pediatrics, Division of Neonatology, Yuzuncu Yil University School of Medicine, Van, Turkey

Med Sci Monit 2014; 20:2799-2805

DOI: 10.12659/MSM.892166

Available online:

Published: 2014-12-26


Background: Hemodynamically significant patent ductus arteriosus (hsPDA) leads to injury in tissues/organs by reducing perfusion of organs and causing oxidative stress. The purpose of this study was to evaluate the oxidant/antioxidant status in preterm infants with hsPDA by measuring the total antioxidant capacity and total oxidant status and to assess neuronal damage due to oxidant stress related to hsPDA.
Material and Methods: This prospective study included 37 low-birth-weight infants with echocardiographically diagnosed hsPDA treated with oral ibuprofen and a control group of 40 infants without PDA. Blood samples were taken from all infants, and than the total antioxidant capacity (TAC), total oxidant status (TOS), and S-100B protein levels were assessed and oxidative stress index was calculated before and after therapy.
Results: The mean pre-therapy TOS level and oxidative stress index (OSI) value of the patients with hsPDA were significantly higher, but TAC level was lower than in the control group. There were no statistically significant differences in the mean post-therapy values of TOS, TAC, OSI, and S-100B protein between the two groups.
Conclusions: hsPDA may cause cellular injury by increasing oxidative stress and damaging tissue perfusion; however the brain can compensate for oxidative stress and impaired tissue perfusion through well-developed autoregulation systems to decrease tissue injury.

Keywords: Ductus Arteriosus, Patent - pathology, Case-Control Studies, Antioxidants, Ibuprofen - therapeutic use, Infant, Newborn, Infant, Premature - metabolism, Oxidative Stress - drug effects, S100 Calcium Binding Protein beta Subunit - metabolism



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