Polymorphism Ala54Thr of Fatty Acid-Binding Protein 2 Gene is Not Associated with Stroke Risk in Han Population of Hunan China
Yanmin Song, Yinxi Long, Lili Long, Ning Zhang, Yunhai Liu
Department of Neurology,, Xiangya Hospital, Central South University, Changsha, China (mainland)
Med Sci Monit 2014; 20:1751-1757
The aim of this study is to make sure whether polymorphism Ala54Thr of gene Fatty Acid-Binding Protein 2 (FABP2) is associated with stroke risk in Hunan Han population of China.
Material and Methods: A total of 206 cerebral infarction (CI), 185 cerebral hemorrhage (CH) and 172 controls were enrolled in our study. Ala54Thr was applied by polymerasechain reaction (PCR) and restriction fragment length polymorphism (RFLP).
Results: No significant difference in Ala54Thr genotypic distribution of FABP2 was observed between stroke group (CI subgroup, CH subgroup included) and controls group. In stroke group, plasma TG level of who carried Ala54Thr, Thr54Thr of FABP2 is significantly higher than who carring Ala54Ala. In controls group, blood lipid is not significantly different among 3 genotypes of Ala54Thr. There is no significant difference in blood pressure and fasting blood sugar between strokes and controls.
Conclusions: Our study shows that Ala54Thr of FABP2 may be not associated with stroke risk but associated with plasma TG level of stroke patients for Hunan Han population of China.
Keywords: Demography, China, Case-Control Studies, Amino Acid Substitution, Ethnic Groups - genetics, Fatty Acid-Binding Proteins - genetics, Gene Frequency - genetics, Genetic Association Studies, Genetic Predisposition to Disease, Logistic Models, Polymorphism, Single Nucleotide - genetics, Risk Factors, Stroke - genetics