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Furosemide with Saline Hydration for Prevention of Contrast-Induced Nephropathy in Patients undergoing Coronary Angiography: A Meta-Analysis of Randomized Controlled Trials

Nana Duan, Jiegang Zhao, Zhuanzhen Li, Pingshuan Dong, Shaoxin Wang, Yuwei Zhao, Liping Wang, Hongyun Wang

Department of Cardiology, First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China (mainland)

Med Sci Monit 2015; 21:292-297

DOI: 10.12659/MSM.892446

Available online:

Published: 2015-01-23

Abstract: Background: The clinical efficacy of furosemide administration in preventing contrast-induced nephropathy (CIN) remains uncertain. This meta-analysis was designed to update data on the incidence of CIN with additional furosemide treatment beyond saline hydration in comparison with hydration alone in patients undergoing percutaneous coronary intervention (PCI).
Material/Methods: A computerized literature search of MEDLINE, EMBASE, and Cochrane databases was performed. Trials were eligible if they enrolled patients undergoing coronary angiography and randomly allocated participants to receive furosemide administration in addition to saline hydration or saline hydration alone. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for combinations of studies.
Results: Five trials involving 1294 patients (640 for additional furosemide treatment and 654 for hydration alone) were included in the meta-analysis. In the synthesis of data, additional furosemide administration had little impact on the incidence of CIN post-PCI compared with peri-procedural saline hydration alone (OR=0.96; 95% CI 0.33–2.84, p=0.95). Moreover, as for the subsequent need for dialysis, there was no statistical significant difference between the 2 groups (OR=1.01; 95% CI 0.38–2.67, p=0.99). Sensitivity analyses did not show any relevant influence on the overall results. There was no publication bias in the meta-analysis.
Conclusions: Furosemide administration did not achieve additional benefit beyond saline hydration in reducing the incidence of CIN in patients undergoing PCI.

Keywords: Contrast Media - adverse effects, Coronary Angiography - adverse effects, Fluid Therapy, Furosemide - therapeutic use, Kidney Diseases - prevention & control, Odds Ratio, percutaneous coronary intervention, Randomized Controlled Trials as Topic, Renal Dialysis, Sensitivity and Specificity, Sodium Chloride - chemistry, Sodium Potassium Chloride Symporter Inhibitors - therapeutic use