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Impaired Aortic Elasticity and Diastolic Functions Are Associated with Findings of Coronary Computed Tomographic Angiography

Hüseyin Ede, Mustafa Fatih Erkoç, Aylin Okur, Ali Rıza Erbay

Department of Cardiology, Bozok University School of Medicine, Yozgat, Turkey

Med Sci Monit 2014; 20:2061-2068

DOI: 10.12659/MSM.892502

Available online:

Published: 2014-10-28

Background: Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Aortic elasticity and diastolic functions are helpful parameters in assessment of CAD. In this study we aimed to learn whether diastolic function and aortic elastic properties measured by echocardiography are associated with coronary calcium score (CACS), epicardial fat volume (EFV), and plaque area measured by coronary tomographic angiography.
Material and Methods: We enrolled 106 consecutive patients suspected of CAD undergoing coronary CTA and transthoracic echocardiography in this prospective study. Total CACS, plaque area, and EFV were calculated via CTA. Aortic stiffness index (ASI) and aortic distensibility (AD) were measured via echocardiography.
Results: The patients with diastolic dysfunctions of any degree had significantly higher ASI, higher CACS, higher plaque area, and EFV. We found that as the ASI increases, the CACS and total coronary plaque area both increase, showing that there is a strong positive correlation between ASI, CACS, and total coronary plaque area. There was a significant correlation between ASI and EFV, but with a lower statistical value.
Conclusions: Aortic elasticity was correlated with CACS and plaque area. Diastolic dysfunction was observed more commonly among patients with higher CACS and EFV. Epicardial fat volume was not as strong as CACS in reflecting aortic elasticity.

Keywords: Coronary Vessels - ultrasonography, Coronary Angiography, Diastole, Elasticity, Tomography, X-Ray Computed