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Serum and Synovial Fluid Nesfatin-1 Concentration is Associated with Radiographic Severity of Knee Osteoarthritis

Yusong Zhang, Xiaolong Shui, Xin Lian, Gang Wang

Department of Orthopedic, Xinhui People’s Hospital of Southern Medical University, Jiangmen, Guangdong, China (mainland)

Med Sci Monit 2015; 21:1078-1082

DOI: 10.12659/MSM.892875

Available online:

Published: 2015-04-15

Background: Nesfatin-1, a member of the adipokine family, has been detected in synovial fluid (SF) from OA patients. This study aimed to determine whether there is a marked correlation of nesfatin-1 levels in serum and SF of knee OA patients with the disease severity of OA.
Material and Methods: This cross-sectional research enrolled 202 knee OA subjects. The Kellgren-Lawrence grading system was utilized to evaluate the severity of knee OA.
Results: Elevated nesfatin-1 concentrations in serum were found in knee OA patients compared with the controls. Nesfatin-1 concentrations were markedly elevated with increased KL grades. Serum and SF nesfatin-1 concentrations were both significantly associated with the disease severity evaluated by KL grading criteria.
Conclusions: Our investigation indicates a marked association of serum and SF nesfatin-1 concentrations with OA disease severity.

Keywords: Case-Control Studies, Calcium-Binding Proteins - blood, DNA-Binding Proteins - blood, Nerve Tissue Proteins - blood, Osteoarthritis, Knee - radiography, Severity of Illness Index, Synovial Fluid - metabolism