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Montelukast Inhibits Pentylenetetrazol-Induced Seizures in Rats

Betul Cevik, Volkan Solmaz, Durdane Aksoy, Oytun Erbas

Department of Neurology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey

Med Sci Monit 2015; 21:869-874

DOI: 10.12659/MSM.892932

Available online:

Published: 2015-03-24

Background: Montelukast is an antiinflammatory drug with an antioxidant property. In this study, we aimed to reveal whether montelukast has a preventive effect against seizures and post-seizure oxidative stress in pentylenetetrazol (PTZ)-induced seizures in rats.
Material and Methods: Of the 48 male Sprague-Dawley rats used in the study, 24 were assigned to EEG recordings (group A) and 24 were assigned to behavioral studies (group B). In group A, the electrodes were implanted on dura over the left frontal cortex for EEG recording. After 10 days, in group A, i.p. saline, 25, 50, or 100 mg/kg montelukast+35 mg/kg PTZ was administered to the rats. EEG was recorded and spike percentage was evaluated. In group B, i.p. saline, 25, 50, or 100 mg/kg montelukast+70 mg/kg PTZ was administered to the rats. Racine’s Convulsion Scale (RCS) and onset times of first myoclonic jerk (FMJ) was used to evaluate the seizures. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined in the brain tissue of animals.
Results: Animals treated with 50 or 100 mg/kg montelukast had significantly lower RCS and significantly increased FMJ onset time compared to the saline-treated animals. Moreover, groups given 25, 50, or 100 mg/kg montelukast had significantly lower MDA and higher SOD levels compared to the saline-treated group. The differences were more pronounced in the 100 mg/kg montelukast-pretreated group (p<0.001).
Conclusions: Montelukast showed anticonvulsant action and led to amelioration of oxidative stress markers in PTZ-induced seizures in rats.

Keywords: Action Potentials - drug effects, Acetates - therapeutic use, Animals, Brain - pathology, Electroencephalography, Malondialdehyde - metabolism, Pentylenetetrazole, Quinolines - therapeutic use, Rats, Sprague-Dawley, Seizures - physiopathology, Superoxide Dismutase - metabolism, Time Factors