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Interleukin-10-1082A/G Polymorphism and Diabetic Nephropathy: A Meta-Analysis

Xia Peng, Jiayun Xu, Pengpeng Wang, Jinjin Zhou, Hong Guo

Department of Nephrology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China (mainland)

Med Sci Monit 2015; 21:890-894

DOI: 10.12659/MSM.892972

Available online:

Published: 2015-03-25

Background: Studies have assessed the association between Interleukin-10 (IL-10) -1082A/G polymorphism and diabetic nephropathy (DN) risk, but the results were inconclusive and contradictory. Therefore, we performed a meta-analysis to investigate the association between IL10-1082A/G polymorphism and DN risk.
Material and Methods: All relevant studies were searched by using PubMed and EMBASE. Data were extracted by 2 authors independently. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated.
Results: Nine case-control studies with 4165 subjects were included in this meta-analysis. We found that IL10-1082A/G polymorphism was significantly associated with an increased DN risk (OR=1.21; 95% CI 1.07–1.37; P=0.002). In the subgroup analysis by race, both Caucasians and Asians with IL10-1082A/G polymorphism showed increased DN risk (OR=1.25; 95% CI 1.03–1.52; P=0.03 and OR=1.25; 95% CI 1.04–1.49; P=0.02), respectively. When we deleted the study without diabetes type, the result was not altered (OR=1.21; 95% CI 1.02–1.44; P=0.03). In the subgroup analysis by sample size, both studies with large sample size and studies with small sample size showed increased DN risk (OR=1.16; 95% CI 1.02–1.31; P=0.02 and OR=1.50; 95% CI 1.14–1.98; P=0.004), respectively.
Conclusions: This meta-analysis confirmed that IL10-1082A/G polymorphism might contribute to the susceptibility for DN.

Keywords: Genetic Association Studies, Diabetic Nephropathies - genetics, Genetic Predisposition to Disease, Interleukin-10 - genetics, Polymorphism, Single Nucleotide - genetics, Risk Factors