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Efficacy of Linezolid, Teicoplanin, and Vancomycin in Prevention of an Experimental Polytetrafluoroethylene Graft Infection Model caused by Methicillin-Resistant Staphylococcus aureus

Bulent Mese, Orhan Bozoglan, Serdal Elveren, Erdinc Eroglu, Mustafa Gul, Ahmet Celik, Harun Ciralik, Halil Ibrahim Yildirimdemir, Alptekin Yasim

Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey

Med Sci Monit 2015; 21:909-914

DOI: 10.12659/MSM.893098

Available online:

Published: 2015-03-27

BACKGROUND: The aim of this study was to evaluate the effectiveness of linezolid, teicoplanin, and vancomycin in prevention of prosthetic vascular graft infections in a vascular graft infection model.
MATERIAL AND METHODS: Fifty rats were divided into 5 groups. A polytetrafluoroethylene graft was implanted on the back of each rat. Methicillin-resistant Staphylococcus aureus (MRSA) strain was inoculated into all rats except Group 1. Group 2 was not given any treatment, Group 3 received linezolid, Group 4 received vancomycin, and Group 5 received teicoplanin. The grafts were removed for microbiological and histological examinations on the 7th day. In addition, C-reactive protein and prealbumin levels and leukocyte counts in obtained blood specimens were determined.
RESULTS: Group 1 did not have infection. Group 2 had bacteria 5.7×10^4 CFU/cm^2. Group 3 and Group 4 had less bacterial growth. Group 5 had no bacterial growth. The number of bacteria was significantly higher in Group 2 than in the other experimental groups and the control group (p<0.001). Although there was no bacterial growth in Group 5, it did not significantly differ from Group 3 and Group 4. Group 2 had a significantly higher CRP level and leukocyte count and a significantly lower prealbumin level than the other groups.
CONCLUSIONS: Linezolid, teicoplanin, and vancomycin are effective in prevention of prosthetic vascular graft infections.

Keywords: C-Reactive Protein - metabolism, Animals, Disease Models, Animal, Leukocytes - pathology, Linezolid - therapeutic use, Methicillin-Resistant Staphylococcus aureus - physiology, Polytetrafluoroethylene - adverse effects, Prealbumin - metabolism, Prosthesis-Related Infections - prevention & control, Rats, Wistar, Teicoplanin - therapeutic use, Vancomycin - therapeutic use