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Preparation of Calcium Phosphate Cement and Polymethyl Methacrylate for Biological Composite Bone Cements

Jun Yang, Kairui Zhang, Sheng Zhang, Jiping Fan, Xinhui Guo, Weiqiang Dong, Shengnan Wang, Yirong Chen, Bin Yu

Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland)

Med Sci Monit 2015; 21:1162-1172

DOI: 10.12659/MSM.893845

Available online:

Published: 2015-04-23

BACKGROUND: We studied the biological safety, biomechanics, and tissue compatibility of calcium phosphate cement and Polymethyl Methacrylate composite bone cement mixed in different ratios.
MATERIAL AND METHODS: CPC and PMMA were mixed in different ratios (3: 1, 2: 1, 1: 1, 1: 2, 1: 5, 1: 10, 1: 15, and 1: 20). PMMA solvent is a general solvent containing a dissolved preparation of the composite bone cement specific to a given specimen to determine biological safety, biomechanics, and tissue compatibility.
RESULTS: The CPC/PMMA (33%) group, CPC/PMMA (50%) group, CPC/PMMA (67%) group, and CPC/PMMA (75%) group were more in line with the composite bone cement without cytotoxicity requirements. The compressive strength of the CPC/PMMA (67%) group and CPC/PMMA (75%) group was 20Mpa–30Mpa, while that of the CPC/PMMA (4.8%) group, CPC/PMMA (6.25%) group, CPC/PMMA (9.1%) group, CPC/PMMA (16.7%) group, CPC/PMMA (33%) group, and CPC/PMMA (50%) group was 40Mpa–70Mpa. Curing time was longer in the CPC group (more than 11 min) and shorter in the PMMA group (less than 2 min). The results of weight loss rate showed that there were no significant differences between the CPC/PMMA group (4.8%, 6.25%, 9.1%, 16.7%, 33%) and PMMA control group (p>0.05). With the decrease of CPC content, the rate of weight loss gradually decreased.
CONCLUSIONS: The CPC/PMMA (50%) group, CPC/PMMA (67%) group, and CPC/PMMA (75%) group provide greater variability and selectivity for the composite bone cement in obtaining better application.

Keywords: Animals, 3T3 Cells, Biomechanical Phenomena, Bone Cements - toxicity, Calcium Phosphates - toxicity, Compressive Strength, Materials Testing, Mice, Microscopy, Electron, Scanning, Osteoblasts - drug effects, Polymethyl Methacrylate - toxicity, Rats, Rats, Sprague-Dawley, Tensile Strength, Tibial Fractures - therapy, Tissue Engineering, X-Ray Diffraction