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22 July 2015 : Clinical Research  

Comparison of Dexmedetomidine versus Propofol for Sedation after Uvulopalatopharyngoplasty

Jihong XuABCDEFG, Chunji JinABCF, Xiaopeng CuiBCDE, Zhou JinADF

DOI: 10.12659/MSM.893884

Med Sci Monit 2015; 21:2125-2133

Abstract

BACKGROUND: Adequate sedation is important in the post-anesthesia care unit (PACU) following uvulopalatopharyngoplasty (UPPP) to ensure patient comfort and decrease the duration of mechanical ventilation (MV), PACU stay, and bleeding. This study aimed to compare dexmedetomidine and propofol as sedatives after UPPP in the PACU.

MATERIAL AND METHODS: We randomized 124 mechanically ventilated adults following UPPP who were managed in the PACU of the General Hospital of the Shenyang Military Region between January 2014 and June 2014, to receive either dexmedetomidine or propofol. The patients in the propofol group received an infusion of propofol (3 mg/kg/h) titrated up to 6 mg/kg/h to attain a Ramsay sedation score ≥4. The dexmedetomidine group patients received 1.0 μg/kg of dexmedetomidine over a period of 10 minutes and then 0.5 to 1.0 μg/kg/h infusion to maintain a Ramsay sedation score ≥4.

RESULTS: Bispectral index (BIS) values were significantly lower in the dexmedetomidine group than in the propofol group at Ramsay sedation scores of 4 and 5. The mean times to spontaneous breathing, waking, and extubation were shorter in the dexmedetomidine group. Tramadol requirement was significantly reduced in the dexmedetomidine group (P<0.05). Incidence of cough during the extubation process in the propofol group was higher than in the dexmedetomidine group. After extubation, Bruggemann comfort scale (BCS) and Rass agitation scores (RASS) were decreased in the dexmedetomidine-sedated patients.

CONCLUSIONS: Dexmedetomidine provides safe and effective sedation for post-UPPP surgical patients and significantly reduces the use of analgesics, with minimal adverse effects.

Keywords: Conscious Sedation - methods, Dexmedetomidine - adverse effects, Hypnotics and Sedatives - adverse effects, Palate, Soft - surgery, Pharynx - surgery, Postoperative Care, Propofol - adverse effects, Sleep Apnea, Obstructive - surgery, Uvula - surgery

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416