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12 March 2015 : Review article  

Utilization of the Organ Care System – A Game-Changer in Combating Donor Organ Shortage

Aron-Frederik PopovABCDEF, Diana García SáezABCDEF, Anton SabashnikovABCDEF, Nikhil P. PatilABCDEF, Mohamed ZeriouhABCDEF, Prashant N. MohiteABCDEF, Bartlomiej ZychABCDEF, Bastian SchmackCDE, Arjang RuhparwarCDE, Klaus KallenbachCDE, Pascal M. DohmenCDEF, Matthias KarckCDE, Andre R. SimonABCDEF, Alexander WeymannABCDEFG

DOI: 10.12659/MSMBR.894020

Med Sci Monit Basic Res 2015; 21:29-32

Abstract

For patients with end-stage heart failure, cardiac transplantation persists to be the gold standard. Nevertheless, the availability of organs remains a main constraint to the treatment. Through mounting usage of ex vivo heart perfusion an increase in organ availability was achieved by reconditioning of organs formerly not regarded as appropriate for transplantation. We propose the future standard application of this state-of-the-art technology to improve the pool of donor organs by evaluating hearts outside standard acceptability criteria.

Keywords: Heart Transplantation - methods, Graft Survival, Organ Preservation - methods, Perfusion - methods, Tissue Donors - supply & distribution

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416