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Star GK Bileaflet Mechanical Valve Prosthesis-Patient Mismatch after Mitral Valve Replacement: A Chinese Multicenter Clinical Study

Hua Cao, Zhihuang Qiu, Liangwan Chen, Daozhong Chen, Qiang Chen

Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, China (mainland)

Med Sci Monit 2015; 21:2542-2546

DOI: 10.12659/MSM.894044

Available online:

Published: 2015-08-27

BACKGROUND: The aim of this study was to investigate the incidence and immediate and mid-term effects of heart valve prosthesis-patient mismatch (PPM) after mitral valve replacement using the GK bileaflet mechanical valve.
MATERIAL AND METHODS: A total of 493 cases of mechanical mitral valve replacement were performed in the departments of cardiac surgery in 7 hospitals from January 2000 to January 2008. The patients included 142 men and 351 women ages 21 to 67 (average age, 48.75). The patients were followed for 3 years after surgery. The effective orifice area index (EOAI), ≤1.2 cm2/m2, was detected during the follow-up period and was defined as PPM. The patients were assigned to either the PPM group or the non-PPM group. Finally, the preoperative, perioperative and postoperative indexes of the 2 groups of patients were compared.
RESULTS: A total of 157 patients had PPM 3 years after surgery. The incidence of PPM was 31.84%. Sixty-three patients in the PPM group received a 25-mm GK bileaflet valve (40.13%), 82 received a 27-mm valve (52.23%), and 12 (7.64%) received a 29-mm valve. There were significant differences in length of intensive care unit stay, duration of ventilator use, length of hospitalization, body surface area, EOAI, mean transmitral pressure gradient, and pulmonary artery pressure between the PPM and non-PPM group (P<0.05). There was a significant difference between preoperative and postoperative pulmonary artery pressures among non-PPM patients (P<0.05); however, there was no statistical difference in preoperative and postoperative pulmonary artery pressures among patients with PPM (P>0.05).
CONCLUSIONS: PPM after mitral valve replacement influences postoperative hemodynamics. Thus, larger-sized GK bileaflet mechanical valves are often used to reduce the risk of PPM.

Keywords: Adult, arterial pressure, China, Follow-Up Studies, Heart Valve Diseases - surgery, Heart Valve Prosthesis - adverse effects, Heart Valve Prosthesis Implantation - adverse effects, Hemodynamics, Mitral Valve - surgery, Postoperative Complications - prevention & control, Prosthesis Design, Pulmonary Artery - physiopathology, young adult