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PTPN22 R620W Polymorphism is Associated with Myasthenia Gravis Risk: A Systematic Review and Meta-Analysis

Xunbo Xiong, Mingqing Xiang, Xianglin Cheng, Yi Huang

Department of Neurology, The First Hospital of Yangtze University, Jingzhou, Hubei, China (mainland)

Med Sci Monit 2015; 21:2567-2571

DOI: 10.12659/MSM.894307

Available online:

Published: 2015-08-30

BACKGROUND: The association between PTPN22 R620W polymorphism and risk of myasthenia gravis (MG) remains controversial. Therefore, we did this meta-analysis to investigate this association.
MATERIAL AND METHODS: We did a comprehensive search in PubMed, Medline, Embase, CNKI (China National Knowledge Infrastructure), and Wanfang electronic databases to retrieve relevant articles. The overall effect was measured by odds ratios (ORs) with its 95% confidence intervals (CIs). Statistical analyses were conducted with STATA software.
RESULTS: Overall, a total of 7 case-control studies with 2802 cases and 3730 controls were finally included in this review. PTPN22 R620W polymorphism was significantly associated with an increased risk of MG (OR=1.57; 95% CI, 1.34–1.82; I2=31%). In the subgroup analysis, thymoma patients were significantly associated with risk of MG (OR=1.59; 95% CI, 1.28–1.98; I2=0%). However, non-thymoma patients with this polymorphism did not have increased MG risk (OR=1.36; 95% CI, 0.86–2.15; I2=77%). In addition, PTPN22 R620W polymorphism showed increased early-onset myasthenia gravis (EOMG) risk (OR=2.38; 95% CI, 1.52–3.71; I2=0%).
CONCLUSIONS: This meta-analysis shows a significant association between PTPN22 R620W polymorphism and MG risk.

Keywords: Genetic Predisposition to Disease, Myasthenia Gravis - genetics, Polymorphism, Genetic, Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics