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Expression of Heat Shock Protein 27 in Benign Prostatic Hyperplasia with Chronic Inflammation

Yuqing Jiang, Xiuli Wang, Yuexian Guo, Wenping Li, Shijie Yang, Wei Li, Wenqing Cai

Department of Urology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland)

Med Sci Monit 2015; 21:2976-2985

DOI: 10.12659/MSM.894562

Available online:

Published: 2015-10-03

BACKGROUND: Heat shock protein 27 (HSP 27) is known as a mediator in immune response and has been recently found to be expressed in prostate cancer. This study aimed to investigate the role of HSP27 in inflammatory BPH.
MATERIAL AND METHODS: Hospitalized BPH patients who received TURP were divided into 4 groups by the presence and degrees of chronic inflammation: non-inflammatory BPH (NI BPH), mild-inflammatory BPH (MI BPH), moderate-inflammatory BPH (MOI BPH), and severe-inflammatory BPH (SI BPH). Expressions of HSP 27, TNF-α, IL-6, and CD3 in prostate tissues and serum of patients were detected by immunohistochemistry and ELISA.
RESULTS: Expression of HSP27 in BPH with histological inflammation was significantly higher than in non-inflammatory BPH. In inflammatory BPH groups, HSP27 expression gradually increased along with increasing inflammation. There was a significant correlation between the expression of TNF-α, IL-6, CD3 and HSP27 among different inflammatory BPH groups.
CONCLUSIONS: HSP27 expression level is associated with the degree of chronic inflammation in BPH and may participate in the pathological process in inflammatory BPH.

Keywords: Antigens, CD3 - blood, Adrenergic alpha-Antagonists - therapeutic use, Biomarkers, Tumor - metabolism, Chronic Disease, Cross-Sectional Studies, Disease Progression, Enzyme-Linked Immunosorbent Assay, Finasteride - therapeutic use, Gene Expression Regulation, HSP27 Heat-Shock Proteins - metabolism, Inflammation - metabolism, Interleukin-6 - blood, Lower Urinary Tract Symptoms - therapy, Prostate - metabolism, Prostatic Hyperplasia - metabolism, Prostatic Neoplasms - metabolism, Transurethral Resection of Prostate, Tumor Necrosis Factor-alpha - blood