Association between XRCC3 Thr241Met Polymorphism and Risk of Breast Cancer: Meta-Analysis of 23 Case-Control Studies
Fan Chai, Yan Liang, Li Chen, Fan Zhang, Jun Jiang
Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, China (mainland)
Med Sci Monit 2015; 21:3231-3240
Studies have shown that gene and environmental factors, such as BRCA1/2 mutations, ionized radiation, and chemical carcinogens, are related with breast cancer. X-ray repair cross-complementing group 3 (XRCC3) is involved in homologous repair of double DNA breaks. It was reported that Thr241Met single-nucleotide polymorphism (SNP) in XRCC3 is associated with increased risk of breast cancer. However, the finding remains controversial. The current meta-analysis aims to determine whether XRCC3 Thr241Met polymorphism is associated with increased risk of breast cancer.
MATERIAL AND METHODS: We performed a meta-analysis of association between XRCC3 T241M polymorphism and the risk of breast cancer. Crude odds ratios (ORs) together with 95% confidence intervals (CIs) were used to assess the strength of association in dominant, recessive, and homozygote models.
RESULTS: We included 23 studies consisting of 13513 cases and 14100 controls in our study. For meta-analysis on the entire database, association of the SNP and breast cancer risk was observed in recessive (OR=1.10, 95% CI: 1.03–1.18, p=0.005) and homozygote (OR=1.09, 95% CI: 1.01–1.18, p=0.023) models. For the analysis on the Asian population subgroup, association of the SNP and breast cancer risk was also observed in recessive (OR=1.615, 95% CI: 1.17–2.228, p=0.004) and homozygote (OR=1.609, 95% CI: 1.154-2.241, p=0.005) models. For the evaluation of the patients without family history of breast cancer, association of the SNP and breast cancer risk was observed in dominant (OR=1.364, 95% CI: 1.096–1.698, p=0.005), recessive (OR=1.336, 95% CI: 0.999–1.788, p=0.051) and homozygote (OR=1.492, 95% CI: 1.085–2.051, p=0.014) models.
CONCLUSIONS: We can conclude that XRCC3 Thr241Met polymorphism might be associated with breast cancer risk, especially in Asian populations and in patients without family history of breast cancer.
Keywords: Breast Neoplasms - genetics, Algorithms, Case-Control Studies, DNA-Binding Proteins - genetics, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Homozygote, Models, Statistical, Mutation, Odds Ratio, Polymorphism, Single Nucleotide, Risk Factors