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Overexpression of miR-210 is Associated with Poor Prognosis of Acute Myeloid Leukemia

Xiaoqiong Tang, Liping Chen, Xinyu Yan, Yuanjie Li, Yuanlin Xiong, Xiaohui Zhou

Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland)

Med Sci Monit 2015; 21:3427-3433

DOI: 10.12659/MSM.894812

Available online:

Published: 2015-11-09

BACKGROUND: MicroRNAs play important roles in regulation of the initiation and progression of AML. MiR-210 is closely related with cancer development; however, whether miR-210 expression level correlates with clinical correlation in AML is unknown. Thus, the aim of this study was to investigate the potential relationship between miR-210 expression and AML prognosis.
MATERIAL AND METHODS: Real-time quantitative PCR was carried out to examine the expression level of miR-210 in bone marrow and serum obtained from AML patients and healthy controls. Then the correlation between miR-210 expression and a variety of important clinical parameters (such as overall survival, relapse-free survival, and prognostic value) were further studied.
RESULTS: The expression level of miR-210 was significantly higher in the bone marrow and serum of AML patients than that of healthy controls (p<0.001). Moreover, miR-210 expression was associated with various AML clinicopathological parameters, including FAB classification and cytogenetics. The serum miR-210 expression level was reduced significantly when the patients achieved complete remission (p=0.02). The high miR-210 expression group had both poorer relapse-free survival (p=0.015) and worse overall survival (p=0.008). In the multivariate analysis model, miR-210 was identified as an independent prognostic marker.
CONCLUSIONS: MiR-210 up-regulation was associated with poor prognosis in AML and it might be useful as a marker for predicting the clinical outcome of AML patients.

Keywords: Adult, Adolescent, Bone Marrow - metabolism, Case-Control Studies, Child, Child, Preschool, Disease Progression, Disease-Free Survival, Gene Expression Regulation, Leukemic, Leukemia, Myeloid, Acute - genetics, MicroRNAs - genetics, Multivariate Analysis, Prognosis, Real-Time Polymerase Chain Reaction, Recurrence, Remission Induction, young adult