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01 July 2015 : Review article  

Continuous-Flow Left Ventricular Assist Device Thrombosis: A Danger Foreseen is a Danger Avoided

Javid FatullayevABCDEF, Mostafa SamakABCDEF, Anton SabashnikovABCDEF, Mohamed ZeriouhBCDF, Parwis B. RahmanianBCDF, Yeong-Hoon ChoiBCDF, Bastian SchmackBCDF, Klaus KallenbachBCDF, Arjang RuhparwarBCDF, Kaveh EghbalzadehCDEF, Pascal M. DohmenBCDF, Matthias KarckBCDF, Jens WippermannBCDF, Thorsten WahlersBCDF, Aron-Frederik PopovBCDF, Andre R. SimonBCDF, Alexander WeymannABCDEFG

DOI: 10.12659/MSMBR.894840

Med Sci Monit Basic Res 2015; 21:141-144

Abstract

ABSTRACT: Left ventricular assist devices (LVAD) are an increasingly implemented therapeutic intervention for patients with end-stage heart failure. A growing body of evidence, however, has shown an elevated risk of device thrombosis, a major complication jeopardizing the patient’s post-implantation survival. To date, multiple causative factors for LVAD thrombosis have been identified, such as internal shear stress, device material, infection, and inadequate anticoagulation. Understanding the mechanisms leading to LVAD thrombosis will not only enable device optimization, but also allow for better patient handling, hence improving post-implantation outcome. In this review we highlight the most commonly identified factors leading to LVAD thrombosis and discuss their mechanisms.

Keywords: Coronary Thrombosis - therapy, Coronary Disease - therapy, Heart-Assist Devices, Ventricular Function, Left

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416