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Cyclooxygenase-2–1195G>A Polymorphism and Head and Neck Squamous Cell Carcinoma Susceptibility: A Meta-Analysis of 1564 Cases and 2346 Controls

Dong-Lai Deng, Ling-Yun Xia, Bing-Yang He, Jing-Mei Guo, Cui Huang, Xian-Tao Zeng

The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China (mainland)

Med Sci Monit 2015; 21:3514-3520

DOI: 10.12659/MSM.894948

Available online:

Published: 2015-11-14


BACKGROUND: The aim of this study was to investigate the association between cyclooxygenase-2 (COX-2) rs689466 (–1195 G>A) polymorphism and susceptibility to head and neck squamous cell carcinoma (HNSCC) by performing a meta-analysis.
MATERIAL AND METHODS: PubMed and Embase were searched for relevant cohort and case-control studies up to 13 March 2015. After data extraction and methodological quality assessment for eligible studies, the overall, subgroup, sensitivity, and cumulative meta-analyses were conducted using the Comprehensive Meta-Analysis software (version 2.2).

RESULTS: Finally, 5 case-control studies involving 1564 HNSCC patients and 2346 healthy controls were included. For overall population, the results of 3 genetic models showed significant association, while the other 2 presented negative association [A vs. G: OR=0.97–1.09, 95%CI=0.97–1.09; AA vs. GG: OR=1.26, 95%CI=1.01–1.57; AA vs. GA: OR=1.21, 95%CI=1.01–1.45); AA vs. (GG+GA): OR=1.20, 95%CI=1.01–1.43; (AA+GA) vs. GG: OR=0.98, 95%CI=0.84–1.15]. Publication bias was not assessed due to the limited number of included studies.
CONCLUSIONS: This meta-analysis indicated that COX-2 rs689466 polymorphism might be associated with increased susceptibility to HNSCC. We also suggest performing more relevant studies in order to enlarge the sample size and obtain more precise results.

Keywords: Case-Control Studies, Carcinoma, Squamous Cell - genetics, Cohort Studies, Cyclooxygenase 2 - genetics, Genetic Association Studies, Genetic Predisposition to Disease, Head and Neck Neoplasms - genetics, Polymorphism, Single Nucleotide, Risk Factors



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