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15 July 2015 : Review article  

Non-Heart-Beating Donor Heart Transplantation: Breaking the Taboo

Javid FatullayevABCDEFG, Mostafa SamakABCDEFG, Anton SabashnikovABCDEF, Alexander WeymannABCDEFG, Prashant N. MohiteABCDEF, Diana García-SáezABCDEF, Nikhil P. PatilABCDEF, Pascal M. DohmenBCDF, Aron-Frederik PopovABCDEF, Andre R. SimonABCDEF, Mohamed ZeriouhABCDEF

DOI: 10.12659/MSMBR.894985

Med Sci Monit Basic Res 2015; 21:153-156

Abstract

Roughly 60% of hearts offered for transplantation are rejected because of organ dysfunction. Moreover, hearts from circulatory-dead patients have long been thought to be non-amenable for transplantation, unlike other organs. However, tentative surgical attempts inspired by the knowledge obtained from preclinical research to recover those hearts have been performed, finally culminating in clinically successful transplants. In this review we sought to address the major concerns in non-heart-beating donor heart transplantation and highlight recently introduced developments to overcome them.

Keywords: Heart Transplantation - trends, Tissue Donors, Tissue and Organ Procurement - methods, Warm Ischemia - methods

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416