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Influence of Pharmacotherapy on Cognitive Functions in Depression: A Review of the Literature

Agata Orzechowska, Maria Filip, Piotr Gałecki

Depratment of Adult Psychiatry, Medical University of Łódź, Łódź, Poland

Med Sci Monit 2015; 21:3643-3651

DOI: 10.12659/MSM.895156

Available online:

Published: 2015-11-24


ABSTRACT: In addition to irregularities relating to the emotional sphere, the cognitive impairment in depression is a part of the clinical picture of this affective disorder. Some of the cognitive deficits may be associated with the severity of psychopathological symptoms of depression, while others are more established and can also occur during periods of remission. The participation in cognitive functioning of people with depression have a number of factors: the severity of symptoms, concurrent anxiety disorders, gender, age, education, duration of the disease, and number of previous episodes, as well as general somatic health or medication used. The pharmacological treatment may have varying impact on the different areas of cognition. Research on pharmacotherapy for depression and its impact on cognitive functioning continue and are very popular among clinicians and researchers. The relationship between antidepressants and cognitive abilities is always modulated by the type of depressive disorder, neurobiological factors, and demographic variables. This article presents a review of the studies relating to assessment of the effects of various antidepressants on cognitive abilities among patients with depression.

Keywords: Antidepressive Agents - therapeutic use, Cognition - drug effects, Depression - psychology, Depressive Disorder - psychology, Drug Therapy, Randomized Controlled Trials as Topic



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