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Association Between Single-Nucleotide Polymorphism (SNP) in miR-146a, miR-196a2, and miR-499 and Risk of Ischemic Stroke: A Meta-Analysis

Jie Zhu, Hongsheng Yue, ChuanWu Qiao, Yun Li

Department of Neurosurgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, Chile

Med Sci Monit 2015; 21:3658-3663

DOI: 10.12659/MSM.895233

Available online:

Published: 2015-11-26

BACKGROUND: The association between 3 well known SNPs – miR-146a C/G (rs2910164), miR-196a2 T/C (rs11614913), and miR-499 A/G (rs3746444) – in pre-miRNA sequences and ischemic stroke (IS) are still conflicting and inconclusive. This meta-analysis aimed to pool previous studies get a more precise assessment of the association between these 3 SNPs and the risk of IS.
MATERIAL AND METHODS: Relevant studies were searched in online databases. The strength of the association between the SNPs and IS were estimated by pooling odds ratios (OR) and 95% confidence intervals (CI) using Review Manager (version 5.3).
RESULTS: Rs2910164 C allele was associated with lower IS risk. But this trend was only observed in Koreans under the allele model (OR=0.81, 95% CI=0.68-0.95, p=0.009), dominant model (OR=0.68, 95% CI=0.50–0.93, p=0.02), recessive model (OR=0.79, 95% CI=0.63–1.00, p=0.05), and homozygous model (OR=0.63, 95%CI=0.45–0.88, p=0.007). Rs11614913 T allele might be associated with higher IS risk under the dominant model (OR=1.45, 95% CI=1.19–1.78, p=0.0003), while rs3746444 A allele might be associated with decreased IS risk under the homozygous model (OR=0.48, 95% CI=0.23–0.98, p=0.04) only in Chinese, but not in Koreans.
CONCLUSIONS: Although the 3 SNPs might be associated with IS, the association varied significantly in different countries.

Keywords: Case-Control Studies, Asian Continental Ancestry Group, Genetic Predisposition to Disease, MicroRNAs - genetics, Polymorphism, Single Nucleotide, Stroke - genetics