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Comparison of Hybrid Surgery Incorporating Anterior Cervical Discectomy and Fusion and Artificial Arthroplasty versus Multilevel Fusion for Multilevel Cervical Spondylosis: A Meta-Analysis

Leyuan Zang, Min Ma, Jianxin Hu, Hao Qiu, Bo Huang, Tongwei Chu

Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing, China (mainland)

Med Sci Monit 2015; 21:4057-4067

DOI: 10.12659/MSM.896584

Available online:

Published: 2015-12-27


BACKGROUND: Few studies have reported the safety and efficacy of hybrid surgery (HS), and some of the studies comparing HS with ACDF have reported conflicting results. We conducted this meta-analysis to clarify the advantages of HS in the treatment of multilevel cervical spondylosis.
MATERIAL AND METHODS: We performed a systematic literature search in PubMed, Medline, and CNKI to identify relevant controlled trials published up to October 2015. The standardized mean difference (SMD) and 95% confidence interval (95% CI) of the perioperative parameters, visual analogue scale pain score (VAS), neck disability index (NDI), and range of motion (ROM) of C2–C7 and adjacent segments were calculated. We also analyzed complications and Odom scale scores using risk difference (RD) and 95% CI.
RESULTS: In total, 7 studies were included. The pooled data exhibited significant differences in blood loss between the 2 groups. However, there was no evidence indicating significant differences in operation time, complications, VAS, NDI, or Odom scale scores. Compared with the ACDF group, the HS group exhibited significantly protected C2-C7 ROM and reduced adjacent-segment ROM.
CONCLUSIONS: The safety of HS may be as good as that of ACDF. Furthermore, HS is superior to ACDF in conserving cervical spine ROM and decreasing adjacent-segment ROM. However, the results should be accepted cautiously due to the limitations of the study. Studies with larger sample sizes and longer follow-up periods are required to confirm and update the results of the present study.

Keywords: Arthroplasty - methods, Cervical Vertebrae - surgery, Diskectomy - methods, Intervertebral Disc - surgery, Randomized Controlled Trials as Topic, Range of Motion, Articular



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