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Relationship Between Carotid Stenosis and Infarct Volume in Ischemic Stroke Patients

Aybala Neslihan Alagoz, Bilgehan Atılgan Acar, Türkan Acar, Alper Karacan, Bekir Enes Demiryürek

Department of Neurology, Sakarya University, Faculty of Medicine, Sakarya, Turkey

Med Sci Monit 2016; 22:4954-4959

DOI: 10.12659/MSM.898112

Available online:

Published: 2016-12-16

BACKGROUND: Stroke is a serious health problem all over the world. Ischemia causes 85% of strokes and 75% of these ischemic strokes occur within the area supplied by the internal carotid artery (ICA).
MATERIAL AND METHODS: This study included 47 acute stroke patients who were in the large-artery atherosclerosis group according to Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification and who had an infarct in the area supplied by the internal carotid artery. We sought to determine whether there was a significant correlation between the infarct volume of the patients as measured by diffusion-weighted magnetic resonance imaging (DW MRI), their National Institutes of Health Stroke Scale (NIHSS), and degree of carotid stenosis as identified by carotid computed tomography angiography (CTA).
RESULTS: A significant correlation was observed between the percentage of carotid artery stenosis and infarct volume (p<0.001). In addition, there was a significant positive correlation between the NIHSS and infarct volume; the correlation was of moderate strength (r=0.366, p=0.001).
CONCLUSIONS: Our findings indicate that the percentage of carotid artery stenosis could be useful in predicting the infarct volume of the stroke.

Keywords: Angiography, Aged, 80 and over, Brain Ischemia - physiopathology, Carotid Artery, Internal - physiopathology, Carotid Stenosis - physiopathology, Cerebral Infarction - physiopathology, Risk Factors, Severity of Illness Index, Stroke - physiopathology