28 February 2017 : Clinical Research
Cross-Over Study Comparing Postprandial Glycemic Increase After Addition of a Fixed-Dose Mitiglinide/Voglibose Combination or a Dipeptidyl Peptidase-4 Inhibitor to Basal Insulin Therapy in Patients with Type 2 Diabetes MellitusNoriko Ihana-Sugiyama1ABCDEF, Ritsuko Yamamoto-Honda12ACDEF, Takehiro Sugiyama3CDE, Tetsuro Tsujimoto1D, Masafumi Kakei4CDE, Mitsuhiko Noda5ADE*
Med Sci Monit Basic Res 2017; 23:36-44
BACKGROUND: Although the efficacy of combination therapy consisting of basal insulin and oral hypoglycemic agents (OHAs) has been shown, which OHAs are the most efficient remains unclear.
MATERIAL AND METHODS: Five patients with type 2 diabetes were enrolled and treated with insulin degludec and metformin as a basal therapy. The patients were randomized in a cross-over fashion to receive a combination of mitiglinide (10 mg) and voglibose (0.2 mg) (M+V) 3 times daily or linagliptin (5 mg) (L) once daily for 8 weeks. After 8 weeks, 2 kinds of meal tolerance tests were performed as breakfast on 2 consecutive days. The first breakfast contained 460 kcal (carbohydrates, 49.1%; protein, 15.7%; fat, 35.2%), while the second contained 462 kcal (carbohydrates, 37.2%; protein, 19.6%; fat, 43.2%). Self-monitoring blood glucose levels were measured at 0, 30, 60, and 120 min after the meal tests, and the increase in the postprandial area under the curve (AUC)0–120 min was determined. The HbA1c, glycated albumin, and 1,5-anhydroglucitol (AG) levels were measured, and continuous glucose monitoring was performed.
RESULTS: The increase in the postprandial AUC0–120 min was significantly smaller in the M+V group than in the L group after both meals. The 24-h average, 24-h standard deviations, 24-h AUC, and mean amplitude of glycemic excursion (MAGE) were similar for both groups and after both meals. The change in 1,5-AG was higher in the M+V group than in the L group.
CONCLUSIONS: The combination of M+V with basal therapy improved postprandial glucose excursion more effectively than L in T2DM patients.
Keywords: Dipeptidyl Peptidase 4, Hyperglycemia, Incretins
Most Viewed Current Articles
05 Jan 2021 : Review articleA Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...
Med Sci Monit Basic Res 2021; 27:e929207
07 Jul 2022 : Laboratory ResearchCytotoxicity, Apoptosis, Migration Inhibition, and Autophagy-Induced by Crude Ricin from Ricinus communis S...
Med Sci Monit Basic Res 2022; 28:e936683
05 May 2022 : Laboratory ResearchCalcitriol Inhibits Proliferation and Potentially Induces Apoptosis in B16-F10 Cells
Med Sci Monit Basic Res 2022; 28:e935139
09 Jun 2021 : Laboratory ResearchVitamin D Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in A549 Cells by Downregulating Inflammato...
Med Sci Monit Basic Res 2021; 27:e931481